The efficiency of Paxil in the treatment of obsessive compulsive ailment (OCD) was demonstrated in two 12‑week multicenter placebo-controlled studies of grown-up outpatients (Studies 1 and 2). Clients in all researches had mild to intense OCD (DSM‑IIIR) regarding mean baseline ratings on the Yale Brown Obsessive Compulsive Scale (YBOCS) total score ranging from 23 to 26. Research 1, a dose-range finding study where individuals were treated regarding fixed dosages of 20, 40, or 60 mg of paroxetine/day demonstrated that daily dosages of paroxetine 40 as well as 60 mg are reliable in the treatment of OCD. Clients receiving dosages of 40 and also 60 milligrams paroxetine experienced a mean decrease of roughly 6 and 7 levels, respectively, on the YBOCS overall rating which was significantly more than the approximate 4-point reduction at 20 milligrams as well as a 3-point decrease in the placebo‑treated individuals. Study 2 was a flexible-dose research comparing paroxetine (20 to 60 milligrams day-to-day) regarding clomipramine (25 to 250 milligrams day-to-day). In this study, clients receiving paroxetine experienced a mean decrease of roughly 7 levels on the YBOCS complete rating, which was dramatically higher than the mean decrease of about 4 factors in placebo‑treated clients.
The adhering to table provides the end result category by treatment team on Global Improvement things of the Clinical Global Impression (CGI) scale for Study 1.